Diazepam Detox

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KEY TAKEAWAYS

Diazepam (Valium) detox is safely managed using tapering schedules or equivalent benzodiazepine doses to: 

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How Is Diazepam Detox Done?

Diazepam detox is done under professional supervision by reducing the daily dose by 5 – 10% every 1 – 2 weeks, or by an eighth of the daily dose every 2 weeks [2].

The recommended tapering schedule for 40mg diazepam daily or less is:

  • Reduction of 2 - 4mg every 1 – 2 weeks until dose is 20mg daily
  • Reduction of 1 - 2mg every 1 – 2 weeks until dose is 10mg daily
  • Reduction of 1mg every 1 – 2 weeks until dose is 5mg daily
  • Reduction of 0.5 - 1mg every 1 – 2 weeks until completely stopped [2]

A substitution of 12.5mg Chlordiazepoxide for every 5mg of Diazepam may be provided as doses can be reduced by up to 50% within 4 days, compared to around 5 weeks for a 50% reduction of diazepam [3] [4].

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Physical Symptoms Of Diazepam Detox

The following symptoms are mitigated with an inpatient diazepam detox, as medical staff carefully manage dosages to alleviate the severity of physical withdrawal symptoms.

GABA Rebound Symptoms

A 15% reduction of GABA receptor activity is a physical symptom of diazepam withdrawal due to restricted GABA–induced signal transmission in the central nervous system, resulting in [1]:

  • Tingling, pins and needles, feelings of electric shocks
  • Heightened sensitivity to light, sound, touch, taste and smell
  • Sore tongue and metallic taste

Hypersensitivity to sensory stimuli and paresthesia typically stop within 4 - 6 weeks; tinnitus and burning sensations in fingers, feet and legs may last for up to 12 months [5]. 

Ataxia

Ataxia is a physical diazepam withdrawal symptom due to: 

  • A 15% reduction in GABA receptor activity and inhibited excitatory neurotransmission during cessation of use, caused by continual loss and degeneration of nerve cells in the cerebellum responsible for muscle coordination and balance [1] [6]
  • Central nervous system toxicity during sudden cessation diminishes the muscle relaxant properties provided by starting doses of 2 – 10mg oral diazepam [7]

One study found that ataxia lasted for over 3 weeks in 50% of patients that stopped taking 60 – 120mg diazepam daily [8].

Vestibular Hypersensitivity

Vestibular hypersensitivity is a physical valium withdrawal symptom due to a 75% reduction of neuron activity in the medial vestibular nucleus, caused by valium’s agonist effect on GABA receptors; leading to [9] [10]: 

  • Dizziness, falling, loss of balance and spinning sensations
  • Blurred vision, disorientation and clumsiness
  • Difficulties when turning around or standing up too quickly
  • Anxiety, frustration and avoidance towards activities requiring postural control [11]

Within 48 hours of cessation, vestibular function returns to baseline levels after taking 10mg valium daily for 2 weeks; although dizziness may persist for up to 8 weeks after withdrawal [12].

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Psychological Symptoms Of Diazepam Detox

The following symptoms are minimised during an inpatient valium detoxification due to ongoing medical supervision and specialised protocols designed to safely manage psychological withdrawal symptoms.

Static Visual Changes

Static visual changes are psychological withdrawal symptoms that occur during valium discontinuation, due to a 37% increase of glutamic acid decarboxylase (GAD) occurring within 12 hours of withdrawal, resulting in [13]:

  • Blurred vision, flashes of light and sensitivity to brightness
  • Self-reported visual hallucinations including tilting floors, inwardly sloping walls and insects crawling on skin [14]

One study found that vision returned to normal within 1 year of valium discontinuation:

  • A 71-year-old woman consuming 100mg valium daily experienced visual field loss due to GABAergic inhibition in the retina and visual cortex
  • Visual fields improved at 6 months whilst taking a reduced dose (morning = 2.5mg and night = 10mg), and vision reverted to normal during a 1-year follow-up examination and cessation of use [15]

One study found that visual disturbances persisted for up to 27 weeks after 12 patients detoxed from valium:

  • 25% experienced visual hallucinations and reported seeing disembodied faces and coats hanging on doors appearing as people; 2 patients hallucinated 2 weeks after the onset of withdrawal and 1 patient after 13 - 27 weeks
  • 75% experienced blurry and double vision, had difficulty reading and reported seeing the world through a mist for up to 2 weeks after the onset of withdrawal, as did 1 patient after 13 – 27 weeks [16]

Intrusive Memories

Intrusive memories are a psychological valium withdrawal symptom due to reduced total sleep time (380 to 287 minutes) and increased waking after sleep onset (15.4% to 32.1%) during withdrawals, resulting in [17]:

  • Reduced REM sleep in detoxing patients (18.1%) compared to controls (21.3%); for each additional 4% of average REM sleep, individuals reported 27% fewer intrusive memories [17] [18]
  • Patients experience vivid thoughts of someone that has not been seen or thought about in years and may see the face of the person in the mirror [14]
  • Intrusive memories typically occur one week after valium withdrawal begins, as sleep efficiency is lowest at this time (64%) [14] [17].

Memory Improvements

Memory improvement is a psychological withdrawal symptom that occurs during valium detoxification due to:

  • A 30 – 50% reduction of immediate and delayed recall performance for valium patients compared to controls, as transfer and consolidation of new information from short – term to long term memory is prevented [19]
  • 27- 33% of valium detox patients have impaired processing speed and sustained attention; non-verbal and verbal memory improve around 6 months after the cessation of use [20] [21] 
  • Cognitive and psychomotor performance (digit span/map location tasks) improves by up to 22% after one year of valium discontinuation, whereas performance declines by 5% in patients continuing to take valium [22]

Return Of Pre-Existing Anxiety

Return of pre-existing anxiety is a psychological symptom of valium detox due to the 15% diminution of GABA receptors in the dentate gyrus, resulting in a 10% increase in anxiety during withdrawal [1] [23].

Pre-existing anxiety typically returns within 1 – 5 days of valium discontinuation and lasts for around 2 weeks; symptoms depend on initial anxiety severity and the presence of co-occurring depression or alcohol use disorders [24].

One study found that 25% of patients experienced rebound anxiety after abruptly withdrawing from taking 15mg valium daily for 4 weeks:

  • All patients had pre-existing generalised anxiety disorder and used valium for around 9 – 18 months previously
  • Scores increased by over 10% on the Hamilton Rating scale for anxiety and the self-rating symptom scale [23]

Returning anxiety symptoms may persist for up to 6 – 24 months after cessation in patients struggling to develop stress management strategies to replace the role of valium [25].

Diazepam Detox Vs Other Benzodiazepines


Diazepam

Alprazolam

Half-life

20 – 80 hours 

12 – 15 hours 

Does Rebound Anxiety Occur?

Yes, in 23% [26] 

Yes, up to 35% experience rebound anxiety and panic attacks [27] 

Seizure Risk Timeframe 

Day 7-14 

Day 2 - 5 

Memory/Cognitive Recovery Timeframe

Around 6 – 18 months

Around 6 months for episodic memory [29]


Clonazepam

Lorazepam

Half-life

18  - 50 hours 

10 – 20 hours 

Does Rebound Anxiety Occur?

Yes, in 29% [28]

Yes, in 63% [26] 

Seizure Risk Timeframe 

Day 7 - 21 

Day 2 - 4

Memory/Cognitive Recovery Timeframe

Up to 2 months for synaptic development and functioning of GABA receptors [30] 

Around 2 - 8 weeks

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Diazepam Detox Timeline

Diazepam Detox Time Period

Patient Presentation 

Medical Interventions 

24 – 48 hours

Rebound anxiety, low mood, irritability, headache

Physical assessment with neurological exam


Diazepam tapered by 5 - 10% or equivalent chlordiazepoxide/clonazepam doses [2]

2 – 6 days

Cravings, fever, nausea, muscle cramps, tremors, insomnia and hypertension

Diazepam or equivalent dose with clonidine, SSRIs and melatonin if necessary 

7 – 10 days

Physical symptoms begin to subside, anxiety and low mood remain

Diazepam is reduced by another 5 – 10% and symptom management medications are adjusted as needed [2]

2 – 12 weeks

Gradual physical and cognitive improvement, irritability, insomnia, anxiety and low mood persist 

Diazepam reduces by 5 - 10% every 1 - 2 weeks until 0mg is reached [2] 


Behavioural and pharmacological interventions are discussed to address persisting psychological symptoms

What Changes Diazepam Detox?

GABRA-2 Gene Variants

CYP2C19 poor metabolisers change valium detox by extending dose reduction schedules to around 20 – 40 weeks from 12 weeks due to [2]:

  • A 40% reduction of oral clearance (CL/F) compared to normal metabolisers, a 5 – 10% reduction every 2 – 4 weeks rather than 1 – 2 weeks may be required [2] [31]
  • An increased valium elimination half-life compared to normal metabolisers (92 vs 56 hours); a dose reduction of 25–50% may be required to prevent oversedation [31]

Rapid CYP2C19 metabolisers change valium detox due to:

  • Reduced elimination half-lives compared to normal metabolisers (40 hours vs 56 hours), increasing the severity of valium withdrawal symptoms (9.5 vs 7.0 = scores on the UKU side effect rating scale) [31] [32]
  • Anxiety, insomnia and depression may last for up to 12 weeks and antidepressants, beta-blockers and melatonin may be prescribed [2]

Elderly Patients

The extended half-life of valium in 61 – 78-year-olds compared to 21 – 33-year-olds (86 hours vs 31 hours) changes valium detox by increasing the dose reduction schedule to around 4 – 5 months due to [33] [34]:

  • 10% dose reductions every 2 weeks until 20mg is reached, then by 5% every 2 weeks until 0mg is reached; doses may be maintained for 1 – 2 weeks before the next reduction if severe withdrawal symptoms persist [35]
  • 10mg oxazepam replacement for every 5mg Valium or Chlordiazepoxide, preventing oversedation and falls to mitigate the 80% increased risk of hip fractures in over 65s using >3mg valium for 28 days or more [36] [37]
  • Withdrawal symptoms are monitored for up to 4 weeks with follow-up appointments every 2 weeks, either in-person or over the phone, until symptoms resolve [2] [35] 
  • 0.1mg clonidine to prevent tremors and seizures with blood pressure and heart rate checks 1 hour after administration; clonidine is withdrawn if dizziness occurs, blood pressure <90/50 mmHg and heart rate <50 [35]

Co-Occurring Alcohol Addiction

 Co-occurring alcohol addiction changes valium detox due to:

  • 16 – 29% of cognitive impairment in 59–88-year-olds is caused by consuming >5mg Diazepam with > 40mg alcohol daily, leading to drowsiness, dizziness and difficulty breathing which may require hospitalisation with 24-hour medical care [38] [39]
  • Requirements for trained staff to treat possible apnea with assisted ventilation to mitigate the 15 – 20% risk of fatal delirium caused by respiratory or cardiovascular collapse [40] [41]
  • Up to 800mg Carbamazepine or 60–180 mg phenobarbital daily may be prescribed to prevent withdrawal seizures in patients abusing alcohol and benzodiazepines [40] [42]
  • Abbeycare uses Chlordiazepoxide tapering schedules to detox over 2 – 3 weeks simultaneously; initial 15 – 40mg doses are required 4 times daily for alcohol plus 12.5mg for every 5mg of patients' current valium dose [4] [43]
  • Outpatient detoxification addresses co-occurring addiction with subsequent withdrawals, e.g. reducing valium dose by 5 – 10% every week until 0mg followed by Chlordiazepoxide for 5 – 10 days [2] [4]

Diazepam Detox At Abbeycare

The diazepam rehab programme at Abbeycare is typically either 4 or 12 weeks long. Alternative treatment lengths can be discussed with the Abbeycare admissions team on 01603 513091. 

Diazepam doses are tapered until 0mg is reached within the first 4 weeks at Abbeycare, and then integrated CBT and mindfulness practices are provided to address pre-existing or rebound anxiety and insomnia.

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About the author

Mischa Ezekpo

Mischa Ezekpo has a Bachelors degree in Psychology from Northumbria
University, and a Masters degree in Childhood Development and
Wellbeing, from Manchester Metropolitan University. Since 2018, Mischa
has written and published work on Addiction, Mental Health, Depression, and Eating Disorders. Content reviewed by Laura Morris (Clinical Lead).

Last Updated: February 27, 2025