KEY TAKEAWAYS
Using cocaine with other drugs results in:
Cocaine And Poly Drug Use
Combined cocaine, alcohol, amphetamines and cannabis use carries a 9-fold increased risk of atherosclerotic cardiovascular disease [2].
The most dangerous combinations of cocaine polysubstance abuse are:
Cocaine Combined With...
Combining Cocaine And Alcohol
Risks Of Combining Cocaine And Alcohol
Polyuse of cocaine and alcohol produces cocaethylene, which incurs an 18-25% increased risk of immediate death vs cocaine alone [3].
Short-Term Effects Of Combining Cocaine And Alcohol
Long-Term Effects Of Combining Cocaine And Alcohol
Mixing Cocaine And Heroin, Fentanyl, Methadone, Or Other Opiates
Risks Of Mixing Cocaine And Opiates
Cocaine and heroin cause combined rhabdomyolysis and ventricular fibrillation, leading to multi-organ failure [8].
Short-Term Effects Of Mixing Cocaine And Opiates
Long-Term Effects Of Mixing Cocaine And Opiates
Mixing Cocaine And LSD
Risks Of Mixing Cocaine And LSD
Cocaine and LSD cause a combination of simple hallucinations, pseudo-hallucinations and illusions [11].
Short-Term Effects Of Mixing Cocaine And LSD
Long-Term Effects Of Mixing Cocaine And LSD
Mixing Cocaine And Cannabis
Risks Of Combining Cocaine And Cannabis
Combined cannabis and cocaine use has a 10% incidence of resulting in drug use disorder [13].
Short-Term Effects Of Mixing Cocaine And Cannabis
Long-Term Effects Of Mixing Cocaine And Cannabis
Mixing Cocaine And Ecstasy/MDMA
Risks Of Mixing Cocaine And Ecstasy/ MDMA
Cocaine is used with MDMA to create an immediate high (15 minutes vs 35 minutes). These combined short highs lead to continued use of both substances sequentially, causing overdose.
Short-Term Effects Of Mixing Cocaine And Ecstasy/ MDMA
Long-Term Effects Of Mixing Cocaine And Ecstasy/ MDMA
Mixing Cocaine And Benzodiazepines
Risks Of Mixing Cocaine And Benzodiazepines
Cocaine and benzodiazepines combined causes overdose as users develop a sensitivity to benzodiazepines [16].
Short-Term Effects Of Mixing Cocaine And Benzodiazepines
Long-Term Effects Of Mixing Cocaine And Benzodiazepines
Mixing Cocaine And Amphetamines And/Or Crystal Meth
Risks Of Mixing Cocaine And Amphetamines And/Or Crystal Meth
Combined cocaine and methamphetamine use decreases activity of frontal limbic moral processing, causing an inability to recognise and process other's emotions [19]
Short-Term Effects Of Mixing Cocaine And Amphetamines And/Or Crystal Meth
Long-Term Effects Of Mixing Cocaine And Amphetamines And/Or Crystal Meth
Mixing Cocaine And Nitrous Oxide
Risks Of Mixing Cocaine And Nitrous Oxide
Cocaine and nitrous oxide combined to cause a breakdown in the nasal respiratory epithelium and the septal and nasal mucosa, leading to nasal collapse [20] [21].
Short-Term Effects Of Mixing Cocaine And Nitrous Oxide
Long-Term Effects Of Mixing Cocaine And Nitrous Oxide
Reasons Behind Mixing Cocaine With Other Drugs
Prolonged High
A cocaine high is shorter than other stimulants (e.g. ecstasy 3-6 hours; LSD 12 hours), causing cocaine users to combine with other stimulants to prolong a high [24] [25].
Avoiding Side Effects
Users combine cocaine with depressants such as benzodiazepines and cannabis to avoid side effects when coming down from euphoria.
Our clients report that poly usage may cause:
Experimenting
Reasons for experimenting with poly-drug usage include:
Who Is Most Likely To Mix Cocaine With Other Drugs?
Early Exposure To Alcohol And Drug Use
11-14-year-olds who have been previously exposed to smoking or drinking are 104% more likely to poly use cocaine [26].
Risk factors that predict polydrug abuse include:
Alcoholics
Chronic alcoholics may mix cocaine to:
Cocaine abuse in alcoholics is symptomatic of those who are attempting to hide alcohol abuse by appearing to have more energy.
This may lead to developing a cross-addiction [28].
LGBTQ+
LGBTQ+ individuals may use multiple substances:
Psychological Effects Of Combining Cocaine With Other Drug Use
Poly cocaine use results in sensation-seeking behaviour such as:
Polysubstance abuse of stimulants causes delusional parasitosis, also known as cocaine bugs, due to the user believing that insects are crawling over their body.
Patients of delusional parasitosis experience feelings of isolation, low self-esteem and depression, which can continue after treatment.
Cocaine Alongside Substance Use Internationally
In the USA, there is a 5-fold increase in death rates due to poly use of cocaine and fentanyl as opposed to cocaine alone. Fentanyl is added due to it being cheaper and easier to obtain than cocaine [31].
62.58% of Albanian cocaine users also use cannabis, and 15.02% also use heroin [32].
This comparatively low amount of polydrug use is due to Albanian gangs smuggling cocaine into the country [33].
In Iran, 51% of those who died from drug abuse had two forms of opiates, stimulants or antidepressants detected in post-mortem samples [34].
Polydrug use is attributed to the high amounts of opium produced in Iran.
95% of regular users in Nigeria poly use cannabis, cocaine, heroin or tranquilisers.
As 46% of Nigerians live below the poverty line, polydrug use is caused by looking for cheaper alternatives to use with cocaine, such as tranquilisers [35].
In Australia, 95% of drug-induced deaths involving 4 or more substances included cocaine. Polydrug use is due to accidentally mixing multiple substances [36].
Reasons for cocaine poly drug abuse internationally are:
When Using Cocaine Combined With Other Drugs Is Not Intentional
Cocaine is 'cut' with other street substances or agents to increase the amount of cocaine that can be sold, thus increasing profit; these include:
Potential side effects indicating other substances have been added to cocaine are:
There is also a risk of cross-addiction, as the user becomes addicted to the other drug unknowingly during cocaine abuse.
How Using Cocaine With Other Drugs Affects Detox
Whilst cocaine detox is usually undertaken without any medication to substitute its effects, cocaine mixed with other drugs requires medication such as:
In polydrug users, the rate of seizures and DTs is increased by 1.1%, and the rate of infections or cardiac complications is increased by 1.8% [39].
Based on our clinical observations, when professionally managed, polydrug detox presents similar risks to detoxing from one drug, assuming professional oversight.
The average detox for polydrug abuse takes between 14-28 days, significantly longer than the average of 7 days for singular drug/alcohol detox.
How Using Cocaine With Other Substances Affects Recovery Attempts
Polydrug users are 6% less likely to attend treatment than cocaine users [40].
Higher brain function improved by 10% in those who had been abstinent from polydrug use for 1 year. Whereas brain function levels were 5% lower than those who had never taken drugs [41].
When Using Cocaine With Other Substances Actually Reduces Risk
Cocaine And Cannabis
The polyuse of cocaine and cannabis reduces latency of cocaine's effects by 1.34% and reduces duration of side effects by 1.34% [42].
Cocaine And Antidepressants
Those who take fluoxetine or desipramine detoxed from cocaine with fewer depressive symptoms and cravings compared to those who did not use any form of antidepressants [43].
Cocaine And Peyote
Combining cocaine with peyote (a cactus with psychoactive properties) causes a reduction in anxiety caused by cocaine use [44].