KEY TAKEAWAYS
Drinking alcohol while taking Pregabalin results in:
Reasons For Mixing Pregabalin & Alcohol
Alcohol and pregabalin (Lyrica) are mixed by users when prescribed, such as:
However, alcohol is also mixed with pregabalin by street users, for example:
Setting | Reasons For Use |
---|---|
Anxiety from alcohol use | Using pregabalin to manage anxiety from |
Epilepsy, chronic pain, or fibromyalgia | Pregabalin mixed with alcohol as |
Using pregabalin to avoid the side effects of | Using pregabalin to avoid seizures caused by |
Chronic drug users | Believing the combination increases the |
Unintentional mixing | Those prescribed pregabalin are not aware |
Risks Of Combining Pregabalin With Alcohol
CNS
Lyrica and alcohol combined depress the central nervous system, causing:
Respiration
Mixing alcohol with Lyrica can lead to respiratory arrest and an increased risk of developing pneumonia or a collapsed lung [3].
Alcohol and pregabalin combined with fentanyl or benzodiazepines can cause respiratory depression [4].
Pre-Existing Liver Issues
In patients with pre-existing non-alcoholic fatty liver disease, 8 days of pregabalin usage combined with occasional alcohol usage resulted in jaundice and elevated liver transaminase levels [5].
Mental Health
Lyrica is typically prescribed for generalised anxiety disorder or convulsions.
As both alcohol and Lyrica depress neurotransmitter activity, the combination counteracts pregabalin's use for anxiety as alcohol increases anxiety after its initial depressive effect on neurotransmitters has worn off.
Those using Lyrica combined with alcohol develop a cycle of:
- 1Using Lyrica to achieve relief from convulsions or generalised anxiety disorder
- 2Drinking alcohol
- 3Going into withdrawal after alcohol consumption ceases
- 4Continuing to use Lyrica to counteract withdrawals, convulsions and anxiety caused by alcohol
Multiple Medications
Amitriptyline
Amitriptyline and Lyrica combined with alcohol lead to blackouts or a loss of consciousness [6].
Oxycodone
Combining oxycodone and Lyrica with alcohol depresses sympathetic activity, causing cardiac arrest or brain damage [7].
Lisinopril
Angioedema caused by lisinopril and Lyrica interaction is exacerbated by alcohol abuse and can lead to throat constriction and suffocation.
Poly-Drug Use
Opiate street drugs (i.e. marijuana, heroin, and oxycodone) combined with pregabalin and alcohol increase the depressive effects of each drug, potentially causing respiratory depression [8].
Stimulant drugs (i.e. LSD, MDMA, and cocaine) combined with pregabalin and alcohol cause:
Tolerance
Regaining Initial Euphoria
A built-up tolerance to Lyrica stops the user from feeling pregabalin's pleasurable or pain-relieving effects.
This encourages further drinking as the user attempts to recapture the initial pleasurable euphoria and pain-relieving effects of Lyrica and alcohol use combined.
Signs Of Overdose
The body does not show outward signs of overdose (vomiting, seizures, and loss of consciousness) under increasing levels of Lyrica tolerance [11].
Seizures
If the user is prescribed pregabalin for epileptic attacks or convulsions, drinking can result in a status epilepticus (a seizure lasting 30 minutes or longer or a series of seizures where the patient does not regain consciousness between seizures) [12].
Motor Skills
Combining pregabalin and alcohol can cause:
At-Risk Groups
Jobs Using Heavy Machinery
Those with jobs that involve high-risk equipment (forklifts, bulldozers or cranes) while mixing pregabalin and alcohol experience risks due to:
Pre-Existing Depression
For those with pre-existing depression, using pregabalin and alcohol concurrently can lead to an increase in suicidal or depressive thoughts [15].
Pregnancy
Taking Lyrica and alcohol while pregnant causes:
Detoxing From Alcohol Alone
Complications when detoxing from alcohol alone while using pregabalin, include:
Special considerations to be in place, once detoxification is complete, include:
Detox From Pregabalin In Alcohol Users
The protocol used by medical practitioners in those who consume, but are not addicted to, alcohol includes:
If doctors are concerned that alcohol usage will affect pregabalin prescription use, they may alternatively prescribe duloxetine or amitriptyline [20].
Pregabalin For Alcohol Withdrawal
Pregabalin can be used for alcohol detoxification, particularly if the patient has:
While pregabalin can be used to treat alcohol withdrawal symptoms, this is not generally advisable for:
Detoxing Combined Pregabalin And Alcohol Addiction
The detoxification protocol for concurrent pregabalin and alcohol addiction differs from protocols of detoxification from alcohol alone in that:
Using Pregabalin & Alcohol In A Controlled Setting
Sequential Detox
If the patient suffers from polydrug and alcohol abuse, a sequential detox treatment plan may be suggested.
A sequential detox prioritises the drugs with the highest doses or the most dangerous side effects, while maintaining use of other substances such as pregabalin and alcohol [23].
Waiting For Treatment
If a patient tells their GP about combined pregabalin and alcohol use, the GP will immediately refer the patient to an appropriate facility, typically a community addiction team or alcohol addiction clinic.
If there is no treatment availability after an assessment, a consultant may advise the patient to continue Lyrica and alcohol use until there is availability to detox.