Ecstasy Detox

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KEY TAKEAWAYS

Ecstasy detox works by: 

  • Medical management of withdrawal symptoms (e.g. dysphoria, bruxism, cravings) with SSRIs, beta-blockers, muscle relaxants and NSAIDs
  • Administering a Withdrawal Questionnaire daily to assess the severity of fatigue, appetite changes, and low mood for up to 12 days after cessation
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Ecstasy Detox Timeline

Ecstasy Detox Time Period

Patient Presentation

Medical Interventions

1 - 3 days

  • Exhaustion/ Fatigue
  • Dysphoria
  • Anxiety and Irritability
  • Urine drug screen, physical and mental state examination
  • 2.5 - 5mg Olanzapine every 6 - 8 hours (max 7 - 10 days)
  • Propranolol, SSRIs (e.g. sertraline) or 75 – 150mg Clonidine every 6 – 8 hours

4 - 6 days

7 - 10 days

  • Anhedonia
  • Sleep disturbances
  • Episodic cravings
  • Anxiety/Agitation

Behavioural and pharmacological interventions are discussed to address persisting symptoms, such as:

  • Alternative antidepressants
  • Referrals for specialist mental health treatment
  • Psychoeducation with sleep hygiene and relaxation techniques

Ecstasy Symptom Management 

There is no medicated detox available for ecstasy, although symptom management and withdrawal scales (e.g. ASCA or AWQ) are used to mitigate and assess the severity of withdrawal symptoms developing within 12 – 24 hours of detox.

Symptom management techniques used in ecstasy detox include: 

  • 75 – 200mg Trazodone at bedtime for up to 10 days to treat insomnia, anxiety and depression or SSRIs (e.g. fluoxetine) after 1 – 4 weeks for persisting depression [1]
  • Magnesium, calcium, and vitamin D supplements whilst encouraging patients to drink at least 2 – 3L of liquids daily to manage dehydration and electrolyte imbalances [2]
  • Propranolol or 75 – 150 (μg) Clonidine every 6-8 hours with ongoing blood pressure checks to minimise anxiety, restlessness and agitation [1] [2] 
  • Daily omega-3 supplements with a minimum of 250–500 mg EPA and DHA combined to stimulate serotonin production following a 46% depletion caused by daily ecstasy use [3]
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Physical Symptoms of Ecstasy Detox 

Appetite Changes

Appetite changes occur in ecstasy detox due to an 18 - 36% decrease in serotoninergic and dopaminergic activity in the frontal cortex and dorsal hippocampus, following a 5-8-fold increase during active use [4] [5] [6].

49% of ecstasy detox patients feel hungrier within 1 - 3 days of cessation because appetite is no longer suppressed by ecstasy; increased appetite peaks during days 3 – 5 and typically subsides by day 7 [2] [7].

Appetite suppression during active ecstasy use leads to weight loss in 43% within 6 months, and some users gain up to 45 lbs within 6 months of recovery due to the rebound effect [8] [9].

Temperature Fluctuations

Temperature fluctuations occur in ecstasy detox because ecstasy takes around 40 hours (5 half-lives) for 95% of the drug to be cleared from the body [10].

Body temperature declines by around 0.2◦C during ecstasy detox, and 18 – 25% experience profuse sweating and hot and cold flushes for up to 2 days, which is exacerbated by [9] [11]:

  • Disruptions in neurotransmission during active use (e.g. 2.05 nmol/l increase of noradrenaline within 1 hour of intoxication) and cessation (e.g. a 46% reduction in serotonin) [3] [12] 
  • Impaired thermoregulation following a 0.2 - 1.6◦C increase in body temperature in 90% of users, developing within 6 hours of drug-taking and lasting between 1 - 3 hours each time [9] [11] [13] 

Bruxism

Bruxism occurs in ecstasy detox because serotonin and dopamine levels increase by up to 501% during active use and remain elevated by around 20% 3 months after cessation [5] [14].

Oral health checks are conducted, and NSAIDs are administered during ecstasy detox because: 

  • 89% experience bruxism that typically lasts between 24 – 48 hours after taking ecstasy, resulting in tight jaw muscles in 85% of users [13] [15]
  • Bruxism persists for over 2 days in 29% of patients, and 60% experience premolar and molar tooth wear, through the enamel and into the underlying bone [15] [16]

Abbeycare's ecstasy detox programme manages bruxism, headaches and muscle tenderness with muscle relaxants (e.g. Baclofen), paracetamol, and ibuprofen every 4 - 6 hours or as needed.

Sensitivity To Light And Sound

Sensitivity to light and sound occurs during ecstasy withdrawal because activity in the somatosensory and locomotor pathways is increased by up to 413% in the central nervous system after daily drug-taking [17].

7.3 - 8.2% experience visual and auditory hallucinations for up to 90 minutes during ecstasy withdrawal, following an increased perception of sound, touch and colour in 85 – 100% whilst intoxicated [9] [13].

One study found that 18 – 23-year-olds experienced sensory overload during days 1 – 4 of withdrawal, after claiming “Every sense is enhanced and ecstasy makes everything feel great” within 2 – 3 hours of intoxication [18].

Psychological Symptoms of Ecstasy Detox

An Emotional Crash

An emotional crash occurs in the first 24-78 hours of ecstasy detoxification due to an 18 – 36% depletion of serotonin and dopamine in the brain, resulting in exhaustion, fatigue, low mood, and dysphoria [4]:


Before An Emotional Crash (Intoxication) 

During An Emotional Crash 

After An Emotional Crash 

 Patient Presentation

Energetic, happy, and friendly 

Exhausted and moody

Irritable, agitated, and restless 

Onset

Around 45 – 60 minutes after drug-taking

12 – 24 hours after cessation

1 – 3 days after cessation

Duration

3 - 6 hours

2- 3 days

7 - 12 days

Depression

4.6% [9]

55% [13] 

37% [7]

Lethargy

7.7% [9]

90% [13] 

53% [7] 

Anxiety/ Agitation

26.7% [9]

40% [13]

39% [7] 

Euphoria

Euphoria occurs during ecstasy withdrawal because serotonin, dopamine, and norepinephrine levels remain imbalanced for up to 14 days after using ecstasy, resulting in: 

  • The re-emergence of euphoria during days 1 – 3 of withdrawal, following the crash phase during the first 12 – 24 hours of detox and euphoric feelings in 100% for up to 6 hours whilst intoxicated [2] [13] 
  • A 161.7% increase in self-reported feelings of euphoria (e.g. excited, energetic) between days 2 – 5 of withdrawal, following a 76.5% reduction in mood ratings from day 1 to day 2 [19]
  • Rebound euphoria accompanied by paranoid ideation and hallucinations in some cases, typically peaking between days 3 – 5 and easing within 1 week [2] 
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Positive Markers Of Ecstasy Detox

Mood Stabilisation

Ecstasy detoxification causes mood stabilisation by: 

  • Providing daily omega-3 supplements with a minimum of 250–500 mg EPA and DHA and SSRIs (e.g. fluoxetine) to increase serotonin, dopamine, and norepinephrine production by 2-to-4 fold in the prefrontal cortex [20]
  • Providing frequent orientation, reassurance, and explanation of detoxification procedures to ease anxiety in patients with perceptual disturbances and giving general health advice about exercise, sleep and nutrition to improve mood [2]
  • Administering 75 – 200mg Trazodone or Clonidine daily to mitigate anxiety, insomnia, and depression and initiating referrals for specialist mental health care for persisting mood disturbances [1] 

One study found that positive mood ratings (e.g. clear-headed, relaxed) were over 50% higher by day 5 of ecstasy withdrawal, in comparison to day 2 [19].

Reduction In Bruxism

Ecstasy detoxification reduces bruxism by:

  • Removing all toxins from the body and addressing serotonin and dopamine imbalances with antidepressants, hydration, sleep, and exercise to ease jaw clenching and teeth grinding within 24 – 72 hours of cessation
  • Administering Baclofen or 100 – 200mg Carbamazepine 1 – 2 times a day to relax jaw muscles and reduce facial pain by controlling electrical impulses in the brain [1]
  • Administering 1mg Paracetamol every 4 hours or 400mg Ibuprofen every 6 hours for headaches caused by temporalis muscle tightness and tenderness in 35 - 58% of detox patients [2] [9]
  • Liaising with dentists to provide soft dental splints and advice on dental hygiene, e.g. regular tooth brushing, flossing to avoid dental disease, using sugar-free chewing gum and fluoride mouthwash

Bruxism eases within 3 days of ecstasy withdrawal and the frequency of headaches caused by jaw clenching decreases by 35.5% from day 2 to 5 [16] [19].

Stabilisation Of Heart Rate And Blood Pressure

Ecstasy detoxification stabilises heart rate and blood pressure by: 

  • Administering Propranolol or 75 – 150mg Clonidine every 6 – 8 hours to relax the blood vessels and facilitate steady blood flow [1]
  • Conducting blood pressure, pulse, and respiratory rate checks every 6 hours during days 1 – 3 and then daily [1]

Heart rate and blood pressure decrease to <100 beats/min and <120/80 mmHg within 12 – 24 hours of ecstasy withdrawal, after 85 - 100% experience tachycardia (>100beats/min) and hypertension (>140/90 mmHg) for up to 6 hours whilst intoxicated [13].

Heart palpitations reduce by 56.6% during ecstasy withdrawal as norepinephrine is no longer increased by 2.05 (nmol/l) once ecstasy is removed from the body [9] [12]. 

Ecstasy Detox Vs...


Ecstasy

Heroin

Alcohol

Detox Duration

7 - 14 days

Around 10 days or 3 – 12+ months with MMT 

5 - 10 days

Withdrawal Symptoms

  • Bruxism
  • Suicide Ideation
  • Emotional Crash
  • Increased Appetite
  • Sweating and Fever
  • Tremors and Shakes
  • Vomiting and diarrhoea

MAT Used?

No

Yes

Yes

Symptom Management Used

  • Paracetamol or Ibuprofen every 4 - 6 hours
  • Omega-3 (250–500 mg EPA and DHA)
  • 75 – 200mg Trazodone + SSRIs (e.g. fluoxetine)
  • 135mg mebeverine 3 times daily
  • Up to 16mg of Loperamide daily
  • 7.5mg zopiclone at bedtime
  • 100mg Thiamine 3 times daily
  • 0.25 - 3mg Haloperidol (<7 days)


Cocaine

Methadone

Detox Duration

Around 1 week

Typically 3 - 6 weeks; some last 6+ months

Withdrawal Symptoms

  • Mood Swings
  • Fatigue and Headaches
  • Lack of motivation and pleasure
  • Muscle aches/pains
  • Goosebumps
  • Yawning
  • Watery Eyes

MAT Used?

No

Yes

Symptom Management Used

  • NSAIDs
  • Antidepressants (e.g. sertraline)
  • Beta-blockers (Propranolol)
  • 20mg Hyoscine every 6 hours
  • 10mg   Metoclopramide every 4-6 hours

How Does Serotonin Depletion Change Ecstasy Detox? 

Serotonin depletion changes ecstasy withdrawal by exacerbating depression, anxiety and irritability in 40 – 60% of patients for up to 6 months rather than 7 – 10 days after cessation [2] [9]. 

Ecstasy detoxification protocols are adapted to address the 46% reduction in serotonergic activity caused by consuming around 200 pills within 5 years by [3]: 

  • Ensuring registered nurses conduct daily mental health assessments, monitor any changes in mental status, and administer medication as needed on an hourly basis [1]
  • Administering higher doses of Trazodone (200 vs 75mg) and Propranolol (160 vs 80mg) to manage depression, insomnia, and anxiety developing within 24 hours of last use [1]
  • Increasing SSRI dosages (e.g. 100mg Sertraline vs 25mg) to minimise dysphoria and low mood caused by ecstasy addiction whilst frequently evaluating patients for signs of psychosis and suicidal thoughts [1]
  • Referring patients with persisting mood disturbances for specialist mental health treatment and providing weekly telephone check-ins for up to 12 months after addiction treatment (or until symptoms have subsided), rather than 3 - 6 months [1] [2] 

Ecstasy Detox At Abbeycare

Ecstasy detox at Abbeycare is provided as part of a 28-day full rehab programme to address ecstasy withdrawal symptoms. Detox and medication provided are personalised, according to decisions by our specialist medical team:

  • Antidepressants and nutritional supplements (e.g. Omega-3, Vitamin D) to manage anxiety, depression and cravings by restoring serotonin, dopamine, and norepinephrine in the brain
  • Baclofen, Paracetamol and NSAIDs to relax the jaw muscles, and minimise headaches caused by jaw clenching, teeth grinding and muscle tightness
  • Beta Blockers (e.g. Propranolol) and 75 – 150mg Clonidine daily to stabilise heart rate and blood pressure during the first 24 – 72 hours of withdrawal 
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About the author

Mischa Ezekpo

Mischa Ezekpo has a Bachelors degree in Psychology from Northumbria
University, and a Masters degree in Childhood Development and
Wellbeing, from Manchester Metropolitan University. Since 2018, Mischa
has written and published work on Addiction, Mental Health, Depression, and Eating Disorders. Content reviewed by Laura Morris (Clinical Lead).

Last Updated: May 16, 2025