Can Alcoholic Dementia Be Reversed?

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KEY TAKEAWAYS

Alcohol-related dementia can be reversed, depending on:

  • The stage of alcohol-induced dementia and whether neuronal mamillary bodies have died
  • The brain regions affected (temporal and frontal lobe damage is partially recoverable, parietal is not) [1]
  • Whether Korsakoff syndrome has developed, a neurological disorder that comprises amnesia and confabulation
  • Thiamine levels < 70 nmol/L hinder dementia reversal [2]
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Can Wernicke's Korsakoff Syndrome Be Reversed?

Wernicke's Encephalopathy (WE)

WE can be reversed by administering  ≥500 mg intravenous thiamine (aneurine), as this reverses symptoms in 73% of patients [3]. 

Research indicates that all alcohol-induced WE patients show symptom reversal when taking 100-1500mg of aneurine [4].   

Administering 100-1500mg of aneurine for WE prevents progression into Korsakoff syndrome and irreversible neuronal damage when administered before neuronal death.

For more advanced cases, 600mg/day of orally administered aneurine combined with 300mg/day of intramuscular aneurine for 2+ months during rehab and aftercare fully reverses WE [5]. 

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Korsakoff Syndrome

Korsakoff syndrome cannot be reversed due to irreparable cell death to the frontal lobes and thalamus; however, patients are given 500mg aneurine intravenously 3 times/day for 3 days to prevent further neuronal cell death [6].

Korsakoff syndrome differs from potentially reversible forms of alcohol-induced dementia due to neuronal death and anterograde amnesia, or the inability to form new memories.

10% of alcohol-dependents have irreversible Wernicke-Korsakoff syndrome, though progression is slowed through clinical management and 1500mg/day aneurine supplementation for 3 days, followed by 250mg/day until clinical improvement slows [7].

Animal studies on rats indicate that irreversible brain damage and Korsakoff syndrome are caused by a 60% reduction in neural plasticity, measured by hippocampal brain-derived neurotrophic factor [8].

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Can Alcohol-Related Brain Damage Be Reversed?

Alcohol-related brain damage can be reversed by 7-35 days of alcohol abstinence [9].

In abstinence, there is a 1.6-fold increase in hippocampal neurogenesis, resulting in new neuronal formation and repair [10].

Research on abstinence following alcohol addiction demonstrates that 5.2% increases in neuronal volume occur in the thalamus over 7.5 months into recovery, indicating a reversal of neuronal damage [11].

Alcohol-related brain damage can be reversed through 2.0mg/kg aneurine supplementation, resulting in an 80% recovery rate for glial fibrillary acidic proteins, a key component of metabolic function and cellular communication [12].  

50% of alcohol-dependent patients show some form of learning and memory impairments, but the reversibility of these impairments depends on the extent of neuronal death [13].

Can Thiamine Deficiency Be Reversed?

Aneurine deficiency can be reversed through intravenous (100mg), intramuscular (100mg) or oral supplementation of aneurine, depending on the severity of the deficiency [14]

Although aneurine deficiency can be reversed, axonal degeneration and brain damage persist in those who are treated with daily aneurine injections for 12-13 days, indicating supplementation does not always fix alcohol-induced intellectual decline [15].

Aneurine deficiency reversal in animal studies on rats demonstrates that aneurine supplementation improves cellular turnover by 60%, measured as a ratio between choline and n-acetyl aspartate [16].

Vitamin B1 deficiency causes a 26-fold increase in inflammatory cytokines, preventing recovery from vitamin B1 deficiency [17].

Can You Partially Recover From Alcohol-Related Dementia?

Partial recovery from alcohol-induced dementia takes from 4 weeks to 7 months; however, the extent of recovery depends on neuroplasticity, age, and the volume of damaged neurons [18]. 

Partial recovery from alcohol-induced dementia depends on whether complete abstinence has been maintained or patients have relapsed during recovery.

Longitudinal studies indicate that relapsing during a 6-month recovery period causes episodic memory to worsen compared to active addiction, whereas those in abstinence returned to normal episodic memory functioning [19]. 

Partial recovery from alcohol-induced dementia occurs due to the reversal of vitamin B1 deficiency and neurogenesis of damaged brain areas; however, this depends on a patient's degree of alcohol-related brain injury.

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How Does Age Change Whether Alcohol-Induced Dementia Can Be Reversed?

Alcohol-dependent patients aged >60 years show a reversal of the brain at 8 months of recovery; however, a complete reversal is not guaranteed [20].

Research studying alcohol's effects on brain volume indicates that the frontal superior cortex decreases volume by 3ml every 45 years, suggesting less reversibility with age [21].

Brain plasticity becomes limited with age, lowering the brain's potential for neurogenesis during recovery from alcohol addiction. 

Rat studies demonstrate that younger rats (8 weeks old) show 7.5% more improvements in spatial learning than older rats (70 weeks old) following abstinence from alcohol, showing younger brains are more likely to show dementia reversal [22].

How Do Genetic Predispositions Change Whether Alcoholic Dementia Can Be Reversed?

APOE-ε4 alleles change the reversibility of alcohol-induced dementia by causing 83.3% increased reelin levels, resulting in 45% lower scores on a general intellectual functioning test compared to controls [23][26].

Females carrying the ApoE4 genotype are genetically predisposed to developing alcohol-related brain atrophy, therefore hindering the recovery process [24].

Those with ε2/ε3 allele bearers exhibit deficits in visual memory compared to ε4/ε3 carriers, suggesting this group of people is more likely to present with irreversible dementia [25]. 

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About the author

Philippa Scammell

Philippa Scammell MSci holds an integrated Master's degree in Psychology
from the University of York and has completed undergraduate statistical studies at Harvard University. Philippa has substantial experience in inpatient psychiatric care (Foss Park Hospital York), Research in Psychology at University of York, and group therapy facilitation (Kyra Women's Project). Philippa writes on clinical psychology and addiction recovery. Content reviewed by Laura Morris (Clinical Lead).

Last Updated: January 9, 2026