Cocaine Detox

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KEY TAKEAWAYS

  • Is sought by 70.2% of cocaine users in active addiction [3]
  • Results in a 45% decreased immune system response after 1 day [1]
  • Combined with pathological gambling requires 4.5% longer recovery [2]
cocaine detox 1

What Is Cocaine Detox?

Cocaine detox is a 28-day non-medicated programme focusing primarily on symptom management.

Cocaine abstinence over 28 days removes the substance from the body and decreases dependence. 

It typically involves continued screening for co-occurring mental and physical health problems.

Depression during the withdrawal phase is treated with SSRIs, and medical supervision is given.

When Is Cocaine Detox Necessary?

It is necessary when:

  • The nasal septum collapses, resulting in loss of sense of smell and nosebleeds
  • Damage to the nasal septum lowers the surface area for absorption, so cocaine can no longer be used effectively
  • Experiencing cardiovascular artery abnormalities - this occurs in 22.8% more cocaine users than non-users and evidences long-term damage [4]
  • Experiencing financial issues as cocaine addiction is expensive - 1 gram of cocaine typically costs £40-£50 for 5-7 uses [5]
  • A user fails to stop using alone, so support and medical supervision are needed
  • Experiencing legal issues as parents may lose custody of children in cases of physical and emotional neglect [6]
  • Peers motivate recovery, as 70.2% seek help for cocaine addiction [3]
cocaine detox 1

Symptoms Of Cocaine Detox

Cocaine Detox Physiological Symptoms

At Abbeycare, we provide you with details of how alcohol detox is completed, including potential withdrawal symptoms, to prepare you for the recovery journey.

The depleted volume of dopamine receptors in cocaine recovery results in hypersomnia.

In the first 72 hours of withdrawal, an increase in REM sleep results in vivid dreams and night terrors [7].

Slow-wave sleep activity is lowest between 4 and 9 days of abstinence, causing minimal deep sleep [8].

Increased appetite from dopamine depletion and circulating hunger hormones result in hunger and weight gain.

Withdrawal results in a suppressed vasodilation response, leading to fluctuations in temperature. 

Cessation results in an inability to regulate body temperature as less dopamine is available for homeostasis.

Cocaine Detox Psychological Symptoms

If you’re concerned about psychological side effects in the detox process, our experienced clinicians are here to address your worries and create a tailored plan for your detox.

12 weeks of cocaine abstinence results in a 40% reduction in cortical levels of 5-HT compared to 1 week, increasing the risk of depression in the mid-stages of detox [9]. 

Mood swings occur due to a lack of quality sleep and decreased dopamine responsible for emotional regulation. 

A lowered volume of dopamine receptors and dysregulated noradrenergic receptors leads to an impaired fight-or-flight response, resulting in high attrition rates for cocaine detox programmes.

Anxiety occurs due to oxidative stress damage observed 4 days into detoxification. 

Indecisiveness results in psychological stress as cocaine is no longer available to help concentration in decision-making.

Symptom Monitoring

Symptom monitoring assesses whether medications are required to manage secondary side effects.

Medications used are:

  • Sertraline: 200mg/day for depression
  • Fluoxetine: 20mg/day for depression
  • Ondansetron: 4mg/kg per day for severe nausea and vomiting
  • Beta-blockers: for heart arrhythmias and anxiety
  • Intravenous fluids: for kidney inflammation prevention

Cocaine Detox Recovery Indicators

Detoxing from cocaine causes: 

  • An 18% decrease in NMSP binding to dopamine receptors after 10 days of withdrawal, removing anhedonia and causing feelings of pleasure from stimuli other than cocaine use [10] 
  • A 35% decreased risk of HIV infection [11] 
  • Memory function improves to pre-addiction levels after 1 year of abstinence [12] 

Timeline

Cocaine Detox Timeframe

How The Patient Presents

Medical Interventions

0 - 24 Hours

  • Irritable
  • Anxious
  • Severely fatigued
  • Headaches
  • Propranolol
  • Modafinil
  • Gabapentin

24 - 72 Hours

  • Nausea and vomiting
  • Depression
  • Agitation and anxiety
  • Insomnia
  • Ondansetron
  • Sertraline
  • Citalopram and beta-blockers
  • Melatonin supplements

3 - 7 Days

  • Anhedonia
  • Difficulty concentrating
  • Sertraline

7+ Days

  • Some exhaustion
  • Anxiety
  • Depression
  • Methylphenidate
  • SSRIs
  • Beta-blockers

Detoxing From Cocaine In Different Settings


Rehab

Outpatient

Timeline Of Treatment

28 days

2+ weeks

Risk Factors

Limited 24/7 supervision

  • Limited supervision
  • Relapse
  • Underlying psychological disorders go unnoticed

Supervision And Medical Care Given?

Yes

Yes

Type Of User

  • High-risk
  • Lack of support system
  • Can afford inpatient care
  • History of relapse
  • Low-risk
  • Good support system
  • Cannot afford rehab
  • No history of relapse

For Polysubstance Use?

Yes - individualistic

Yes


Hospital

At Home

Timeline Of Treatment

7-10 days

2+ weeks

Risk Factors

Limited risk factors

  • Limited supervision
  • Reoccurring drug use 
  • Underlying psychological disorders go unnoticed

Supervision And Medical Care Given?

Yes

No

Type Of User

  • High-risk
  • Lack of support system
  • Co-occurring health problems
  • History of reoccurring drug use
  • Low-risk
  • Excellent support system
  • Cannot afford rehab
  • No history of reoccurring drug use

For Polysubstance Use?

Yes

No

ImmediateHelp

Cocaine Detox Vs Other Drugs


Detox Symptoms

Detox Duration

Cocaine

  • Anhedonia
  • Agitation

28 days

Alcohol

  • Tremors
  • Hallucinations

5-7 days

Heroin 

  • Muscle and bone aches
  • Dilated pupils
  • Watery eyes and runny nose

7-10 days

Benzodiazepines

  • Paraesthesia
  • Muscle spasms
  • 1-2 weeks for short-acting
  • 2-8 weeks for long-acting

Methamphetamines

  • Psychosis
  • Cognitive impairment

1-5 weeks

Cannabis

  • Depersonalisation
  • Stomach pain

10-20 days

  • Severe muscle and joint pain
  • Gastrointestinal problems

7-20 days


Withdrawal Risks

Detox Drugs Used

Cocaine

  • Severe depression
  • Weight gain

None

Alcohol

  • Delirium tremens
  • Alcohol withdrawal syndrome
  • Benzodiazepines
  • Anticonvulsants

Heroin 

  • Gastrointestinal distress
  • Increased blood pressure
  • Buprenorphine
  • Subutex
  • Suboxone
  • Buvidal

Benzodiazepines

  • Seizures
  • Heart palpitations

Small dose Diazepam

Methamphetamines

Suicidal ideation

None

Cannabis

  • Irritability
  • Weight gain

None

Fentanyl

  • Dehydration and electrolyte imbalance
  • Lacrimation
  • Methadone
  • Buprenorphine
  • Buvidal


Relapse Rates

Cocaine

24% [10]

Alcohol

66% [11]

Heroin 

75% [12]

Benzodiazepines

42.6% [13]

Methamphetamines

61% [14]

Cannabis

6.63% [15]

Fentanyl

Up to 95% [16]

What Factors Change Detoxing From Cocaine

Pre-Existing Medical Conditions

The following factors that change cocaine detox are either assessed ahead of admission, or a client is referred to an appropriate care facility for detox. Please speak to our admission team for more information.

Pre-existing chronic stress (cortisol ≥0.69 µg/dL) results in a 2.39 times increased chance of dropout from cocaine treatment programmes [17]. 

For pre-existing diabetes, withdrawal takes place in a hospital due to the risk of ketoacidosis from circulating cortisol.

Immune system responses decrease by 45% one day after substance cessation, so cases of weakened immunity require nutritional support and supplements to prevent immune suppression [1].

Pre-existing depression causes a 79% increased likelihood of intense cravings, so there is a shift in focus towards trigger avoidance [18].

In cases of malnutrition, the programme integrates nutritional assessments and support, as nutritional deficiencies exacerbate fatigue experienced in cocaine withdrawal.  

Pre-existing bipolar disorder requires treatment with lithium to regulate mood before recovery begins, delaying the programme until patients are stable.

Duration And Severity Of Cocaine Usage

Daily cocaine administration over 2 weeks causes reduced dopamine responses in 75% of neurons, so long-term users require more support with managing triggers as the brain is less able to regulate pleasure [19]. 

Short-term use typically results in fewer and less severe symptoms of withdrawal that do not always require a full 28-day detox.

Infrequent use leads to decreased psychological dependence, so not all 28 days for recovery are required. 

Repetitive cardiovascular strain from binge use warrants beta blockers that are used before detox can start.

Overdose results in seizures in 7.9% of cases and requires close monitoring and anticonvulsant medication before recovery can begin [20].

Detoxing from combined ketamine use results in extreme anhedonia that requires the use of SSRIs as well as symptom management.

Co-Occurring Addictions

Early-onset and long-term cannabis use exacerbates cocaine withdrawal symptoms. 

5+ days of cannabis use in the 30 days before treatment leads to higher scores on the Beck Depression Index 3 weeks after treatment [21].

3+ years of cannabis use increases the number of re-hospitalisations for cocaine misuse 2.5 years after the first assessment [22].

The byproduct cocaethylene from the combined use of alcohol and cocaine has a half-life of 2 hours compared to 1 hour for cocaine alone, providing longer periods for withdrawal and detoxification for co-occurring addiction.

Patients with co-occurring pathological gambling spend, on average, 4.5% longer in recovery due to cross-overs in craving [2].

Co-occurring opioid addiction requires a medicated detox, as quitting without treatment is life-threatening.

Improvements In Treatment

If withdrawal from cocaine was treated medically, the following may be evident:

  • 200mg/day of Modafinil leads to 8.9% more substance-free days compared with a placebo, increasing the length of abstinence [23]
  • 400mg/day of Modafinil results in 56.6% more days of consecutive abstinence, making treatment more effective for longer [23]
  • Patients using Topiramate have a 2.43 times increased chance of continued abstinence compared to a placebo [24]
  • Topiramate improves day-to-day functioning and craving compared to placebos
  • Disulfiram is effective at reducing substance use when used with CBT, reducing the recovery timeframe
  • The use of Transcranial Magnetic Stimulation minimises substance use by 50% compared to a placebo, evidencing stronger adherence to recovery programmes [25]

Pregnancy

High arterial blood pressure (>85 mm Hg) seen in withdrawal increases the chances of pre-eclampsia in pregnant women by 27% [26].

85.7% of patients experience an abnormal heart rhythm during the first 3 weeks of abstinence, and this affects 10 in 100,000 pregnancies [27] [28].

Recovery includes vitamin deficiency testing and supplementation of folic acid and calcium to support foetal development in pregnancy.

Iron supplements prevent iron deficiency anaemia and lowered birthweight in pregnancy, so this changes the supplement regime for cocaine treatment. 

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When Is Cocaine Withdrawal MOST Appropriate?

  • In cases of low psychological control that require inpatient treatment so patients can be professionally monitored
  • In low-stress pregnancy, because increasing cortisol >0.69 µg/dL puts stress on the foetus [29]
  • In ADHD when extended methylphenidate is prescribed, decreasing the Addiction Severity Index by 4.9 in this population [30]
  • In ADHD because 60% have one other diagnosed psychiatric disorder, necessitating inpatient care [30]

When Is Cocaine Withdrawal Not Appropriate?

  • For pregnant women with pre-eclampsia because this is the leading cause of death in pregnancy [31]
  • When Sumatriptan is prescribed as combined with withdrawal this causes blood pressure to increase over 6 ± 5 mm Hg [32]
  • In cases of good psychological control as recovery may be done at home or outpatient - under professional medical advice only
  • In cases of combined fibromyalgia - an 8.6% reduction in dopamine in the substantia nigra worsens pre-existing fatigue and anhedonia [33]
  • For dual heroin/cocaine addiction as this requires medication
  • When there is a history of relapse - 28-day treatment extends to a 12+ week programme with aftercare planning

What To Avoid During Cocaine Detox

Daily sugar consumption over 21 days increases extracellular dopamine by 130%, amplifying cocaine cravings [34]. 

Consumption of only 100mg of caffeine, equivalent to a cup of coffee, is enough to induce anxiety and interfere with overcoming addiction [35].

Engaging in adrenaline-inducing activities stimulates dopamine release and cravings similar to cocaine.

Continuing gambling when this formerly occurred during cocaine use acts as a trigger due to cross-addiction.

Engaging in work deadlines during recovery triggers stress that can lead to relapse in some cases, especially when the substance is used as a coping mechanism.

Isolation during recovery leads to a lack of moral support from friends and family that is needed for abstinence.

Cocaine Detox At Abbeycare

At Abbeycare, each client is assessed individually before admission to determine whether detoxification is suitable.

Comprehensive care plans consider all needs and concerns and are used throughout the entire treatment process.

Detoxification is offered as part of a rehab programme and includes extensive aftercare planning for when our patients are ready to leave Abbeycare.

Please speak with our admissions team for further advice.

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About the author

Philippa Scammell

Philippa Scammell MSci holds an integrated Master's degree in Psychology
from the University of York and has completed undergraduate statistical studies at Harvard University. Philippa has substantial experience in inpatient psychiatric care (Foss Park Hospital York), Research in Psychology at University of York, and group therapy facilitation (Kyra Women's Project). Philippa writes on clinical psychology and addiction recovery. Content reviewed by Laura Morris (Clinical Lead).

Last Updated: July 18, 2025