Cannabis Detox

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KEY TAKEAWAYS

Cannabis detox:

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How Is Cannabis Detox Done?

There is no specific medication for marijuana detox, but withdrawal symptoms are managed medically using SSRIs, NASSAs and melatonin until the body eliminates Tetrahydrocannabinol (THC). 

Short-term anxiety medications are prescribed, such as Buspirone, taken 5mg 2-3/day; however, doses can be increased to a total of 45mg/day for those with pre-existing anxiety.  

The process typically lasts between 7-10 days, with mild cannabis cravings and depression persisting for up to 3 weeks into rehab - about five months shorter than protracted depression in opioid withdrawal.

Cannabis-hyperemesis syndrome involves nausea and vomiting during active cannabis addiction and for 5-20 days in detox; however, this is appropriately treated with anti-nausea medications [1].

Physical Symptoms Of Cannabis Detox

Physical withdrawal symptoms may appear during treatment. However, these are appropriately managed with medications to ensure a comfortable detox.

Physical withdrawal symptoms are:

  • Night sweats, occurring in 3.9%, caused by the slow release of THC from fat cells over ~3 weeks that binds to CB1 receptors in the hypothalamus [2]
  • Struggling to stay asleep, as patients spend on average 75% of sleeping sessions asleep compared to a 90% healthy average; however, this increases to 85% when lofexidine is used in detox [3] [4]
  • Vivid dreaming or nightmares, occurring in 17.3%, caused by a rebound of REM sleep as cannabis is no longer available to suppress the hypothalamus responsible for REM sleep and dreaming [2]
  • Sensitivity to lights and sounds, as cannabis no longer suppresses CB1 receptors in the thalamus responsible for sensory relay of input (e.g., bright lights and noise)
  • Decreased appetite due to a rebound effect of THC as it is no longer available due to CB1 receptor desensitisation - cannabis is no longer available to stimulate these receptors, resulting in eating less
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Psychological Symptoms Of Cannabis Detox

Psychological withdrawal symptoms are monitored in detox so that any medications can be offered as needed. These symptoms are not guaranteed and will vary on a case-by-case basis.

Psychological withdrawal symptoms are:

  • Onset of paranoia in 24-72 hours caused by overactivation of CB1 receptors; however, this is treated with Buspirone [5]
  • Overestimating or underestimating time, caused by a rebound effect , or overreaction, of CB1 receptors in the basal ganglia, a brain area responsible for time perception
  • Emotional blunting occurs due to the absence of cannabinoid stimulation from THC; however, this typically resolves in 3-4 weeks as the endocannabinoid system readjusts
  • Low mood, depression and anxiety are caused by a 15% reduction in CB1 receptors; however, CB1 functionality returns after 2 days of detox [6]
  • Anhedonia occurs in detox due to unresponsiveness to naturally occurring endocannabinoids, such as anandamide, that regulate mood
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Recovery Markers Following Cannabis Detox

Detoxing from cannabis: 

  •  Reduces FEV1/ FVC by 1.9%, decreasing chronic bronchitis symptoms to those of those who have never smoked cannabis [7]
  • Improves memory function by 0.2% every week  in the first 4 weeks of abstinence [8] 
  • Decreases anxiety and improves sleep quality by 5% after 12 weeks [9] 

Inpatient Cannabis Detox Vs Natural Remedies


Inpatient Cannabis Detox

THC Detox Drinks

How This Works

Residential care that uses symptom-managed detox

Claims to increase urination to flush out THC

Medical Support

Yes

No

Removal From Triggers, Associations, etc Of Addictions

Yes

No

Dangers

Low risk - Under strict supervision

Dehydration due to being a diuretic

Efficacy

High efficacy - Targets both physical and psychological dependence

Low efficacy - Doesn’t target psychological addiction


Natural Substances

How This Works

Green tea and cranberry juice claim to increase urination 

Medical Support

No

Removal From Triggers, Associations, etc Of Addictions

No

Dangers

Green tea has a high caffeine content

Efficacy

Low efficacy - Limited research to suggest natural remedies work 

Cannabis Detox Timeline

Cannabis Detox Time Period

How The Patient Presents At This Stage

Medical Interventions At This Stage

24 - 48 Hours

Nervousness and anxiety


Insomnia


Irritability

Sertraline, Buspirone (5mg 2-3 times/day)


Melatonin or Trazodone

2 - 6 Days

Strong cannabis cravings


Cannabis withdrawal depression


Cannabinoid Hyperemesis Syndrome


Loss of appetite

Diazepam, SSRIs


Ibuprofen


Metoclopramide

7 - 10 Days

Mild cannabis cravings


Depression


Anger and aggression

Fluoxetine, Venlafaxine, and Mirtazapine

What Changes Cannabis Detox

Genetics

There is a 3-fold increase in circulating Tetrahydrocannabinol during treatment for those with the CYP2C9*3/*3 variant, as the enzyme that breaks down THC only works at 7% capacity  [10].

Genetic variations at CYP2C9, notably the CYP2C9.2 and CYP2C9.3, are 30% less effective at metabolising Tetrahydrocannabinol in the liver, resulting in the later onset of cannabis withdrawal symptoms and prolonged withdrawal period lasting over 4 weeks [11].

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Body-Fat Composition

The tetrahydrocannabinol content stored in fat molecules is 10 times greater than that in surrounding tissue, resulting in those with a high body fat percentage (>32%) experiencing an extended treatment period lasting over 14 days, compared to 7-10 days [12].

A high body fat percentage (>32%) leads to  prolonged withdrawal symptoms, such as cannabis cravings and night sweats, for up to 50% longer.

A high body fat percentage (>32%) and food deprivation results in a 50% increase in circulating Tetrahydrocannabinol levels, so treatment focuses on nutritional support and sufficient caloric intake during detoxification [13].

Females have, on average, 7% more body fat than males, typically resulting in a longer period for cannabis withdrawal; however, this depends on a patient's exact body fat percentage.

Psychotic Disorder Predisposition

A predisposition to psychosis may lead to auditory and visual hallucinations that require short-term treatment using Quetiapine or Olanzapine; however, symptoms may not present until Day 7, so continued monitoring is needed [14].

A predisposition to psychosis, such as a family history of psychosis, requires 15-minute observations as necessary to assess the need for antipsychotic medication.

If psychotic symptoms persist throughout treatment, psychotherapy is delayed until the later stages of rehab to ensure active engagement and prevention of cannabis relapse.

Self-Medication

ADHD patients self-medicating also require an in-depth assessment of current diagnoses and medication regimes - if ADHD medications are not being used, these are offered as part of an individual care plan.

Whilst concurrent ADHD and chronic pain are treated during the programme, addiction rehabilitation units are not responsible for the diagnosis and ongoing support for these disorders.  

26.7% of chronic pain patients experience pain and irritability, necessitating the use of ibuprofen and gabapentin in withdrawal [15].

Cannabis Detox Misconceptions

Common misconceptions of marijuana detox are:

  • Drinking water speeds up treatment: there is no research suggesting that increasing urination through drinking water affects the breakdown of Tetrahydrocannabinol in the body
  • Tetrahydrocannabinol is fully excreted within 24 hours: cannabis is a lipophilic substance stored in fat tissue and takes 7-10 days to break down
  • Exercise alone reduces Tetrahydrocannabinol levels: detectable Tetrahydrocannabinol levels in urine do not differ from baseline after 45 minutes of exercise [15]
  • Fasting speeds up Tetrahydrocannabinol release: the concentration of detectable Tetrahydrocannabinol in urine does not differ from baseline after a 24-hour fast [15]

Cannabis Detox At Abbeycare 

Cannabis detox at Abbeycare takes place within the first 7-10 days of a full 28-day rehab programme.


Withdrawal symptoms are managed during a symptom managed detox at Abbeycare, ranging from medical intervention (e.g., melatonin to aid restful sleep) and pastoral care to ease worries about the detox process.


This process is completed in our inpatient centres so that symptoms are monitored and a healthy, balanced diet is implemented, especially when patients lose appetite during this phase.

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About the author

Philippa Scammell

Philippa Scammell MSci holds an integrated Master's degree in Psychology
from the University of York and has completed undergraduate statistical studies at Harvard University. Philippa has substantial experience in inpatient psychiatric care (Foss Park Hospital York), Research in Psychology at University of York, and group therapy facilitation (Kyra Women's Project). Philippa writes on clinical psychology and addiction recovery. Content reviewed by Laura Morris (Clinical Lead).

Last Updated: February 27, 2025