What Is Cannabis Addiction

Call our local number 01603 513 091
Request Call Back

Call our local number 01603 513 091
Request Call Back
Call our local number 01603 513 091
Request Call Back
quotation_mark

KEY TAKEAWAYS

Cannabis addiction is:

  • The compulsive use of cannabis, despite experiencing negative consequences such as psychosis and poor concentration
  • Physical tolerance - cannabinoid receptors habituating, typically from average use of 1-4 joints/day [1]
  • Experiencing cannabis withdrawal symptoms, notably nausea and sweating, during periods of abstinence 
whatiscannabisaddiction 1

Physical Indicators Of Cannabis Addiction

Physical indicators of cannabis addiction are:

  • Red bloodshot eyes are a physical indicator of cannabis addiction caused by the widening of the eye capillaries, lasting from 3-24 hours
  • Dry and itchy eyes due to a 60% reduction in tear volume from 4m/kg of cannabis, caused by THC activating CB1 receptors [2]
  • Dry mouth, or "cottonmouth," occurring in 69.6% of users and caused by inhibition of the saliva glands [3]
  • Oral cancer caused by cannabis smoke, as it contains 50% more carcinogenic substances, such as nitrosamines, compared to traditional tobacco smoke [4]
  • A hoarse voice, as 66% of cannabis users show discoloured and inflamed vocal cords [5]
  • Tooth sensitivity and decay, caused by saliva acidity increasing by 8% [6]
  • Increased appetite, as addiction causes the hunger hormone ghrelin to increase by 37.3% [7]
  • A phlegmy cough and excess mucus caused by inflammation of the respiratory system
  • Tachycardia and heart arrhythmias caused by a 20-100% increase in heart rate during active cannabis use [8]
whatiscannabisaddiction 1

Psychological Indicators Of Cannabis Addiction

Psychological indicators of cannabis addiction are:

  • Forgetting the placement of objects, caused by a 50% reduction in spatial memory functioning [9]
  • Experiencing challenges with switching from one task to another due to a ~15% reduction in cognition and problem-solving [10]
  • Overestimating time, caused by inhibition of the cerebello-thalamo-cortical circuit, a brain network responsible for time perception, resulting in an inability to finish tasks on time [11]
  • Paranoia and schizophrenia symptoms, as scores on the Paranoid Visual Analogue Scale increase by 0.91 for every unit increase in THC consumed [12]
  • Delusional beliefs increase by 50% upon knowingly consuming THC, compared to unknowingly consuming the substance when it is laced in vapes [13]
  • 28% of cannabis users with depersonalisation-derealisation disorder report using 100-500 times prior to onset, and results in symptoms such as detachment and difficulty concentrating [14]
ImmediateHelp

Vulnerable Groups


More/Less Vulnerable

Why?

Teenagers

More vulnerable

Peer pressure


High risk-taking behaviour; experimenting with illicit substances


Unaware of cannabis health risks

More vulnerable

Self-medicate psychosis


Relieve intrusive thoughts

Men

More vulnerable

Greater dopaminergic activation compared to females when using cannabis

Chronic Stress

More vulnerable

Self-medication

Chronic Pain

More vulnerable

Self-medication, particularly during flare-ups

Why Is Cannabis Addiction Considered A Precursor To Other Addictions?

Biological Mechanisms

Up to 8mg/kg of cannabinoids over 11 days results in cocaine sensitivity, particularly in adolescents, caused by shared activation of dopaminergic pathways [15]. 

Cannabis binds to CB1 receptors that inhibit GABA release, resulting in dopamine deficits that make the brain sensitive to the effects of cocaine and MDMA, resulting in polysubstance misuse.

(Read about detox from ecstasy.)

A 2024 study by Peters and colleagues demonstrates that WIN55,212-2, a type of synthetic cannabinoid that mimics THC, increases dopamine output by 150%, reinforcing drug-seeking behaviour as dopamine receptors become habituated [16].

Early Onset Of Usage

Weekly cannabis use in adolescence causes a 7-fold higher rate of daily use in early adulthood and a 2-fold higher rate of alcohol consumption, leading to future dual-substance dependency [17].

Cannabis is a precursor to tobacco addiction because 34% of 24-year-olds dependent on cannabis and tobacco previously used cannabis in adolescence [18].

Animal studies in rats show that adolescent exposure to a 30 mg/kg infusion of cannabis results in a 67% increase in self-administered heroin use in adulthood [19].

GetConfidentialHelp

Patterns Of Drug Use

44.7% of lifetime users of cannabis develop cross-addictions with other illicit substances, such as cocaine, hallucinogens and heroin [20].

(For more on hallucinogens, read about LSD addiction here, and about LSD detox here.)

50% of cannabis users with co-occurring alcohol use disorder initially used cannabis alone [21].

Adolescent THC exposure causes increased cocaine-induced activation in the hypothalamus, resulting in motivation to use cocaine and subsequent addiction [22].

Long-Term Effects Of Cannabis Addiction

A 2-5% reduction in orbitofrontal cortical matter in cannabis addicts causes misinterpretations of sensory input, resulting in auditory and visual hallucinations even during periods of non-use [23].

Chronic bronchitis is a direct long-term effect of cannabis dependency due to inhalation of smoke and vapour, resulting in inflammation, coughing and wheezing.  

Cannabis Hyperemesis Syndrome is a gut-brain disorder caused by weekly+ cannabis use in 97.4% of users, resulting in nausea and vomiting, requiring hot baths to relieve symptoms [24].

Cannabis addiction increases the rate of hospitalisation for psychotic episodes by 26% for those with pre-existing psychosis [25].

What Changes Cannabis Addiction?

Legality Of Cannabis

Since the introduction of legalised medical cannabis in the UK, 10.9% of illicit cannabis users report increased recreational use, maintaining cannabis addiction [26].

21% of cannabis users report using illicitly obtained cannabis for medical and therapeutic purposes since the medical legalisation [27].

The legalisation of medical cannabis has increased the recreational use and subsequent addiction of cannabis in young people by 2-3.5%, making addiction more prominent in this population [28].

As cannabis is a Class B drug, users underestimate its harmful effects compared to Class A substances, such as ketamine, resulting in denial about its potential to cause addiction. 

Cannabis Strains

Compared to 0.5mg/kg of oral delta-9-thc alone, the combination of delta-9-thc  (0.5mg/kg) and CBD (1mg/kg) reduces the self-reported perception of addiction [29]. 

Recent strains of marijuana contain 17-28% delta-9-thc with 0.09-0.2% CBD, resulting in addiction [30].

Delta-9-thc users not exposed to CBD show an 11% reduction in hippocampal volume and memory function compared to using marijuana containing both in addiction [31].

43-45% more users of sativa cannabis strains report feeling motivated and focused compared to using indica [32].

Indica strains, compared to sativa, cause a 59% increase in tiredness and relaxation [33].

Gender

Female users addicted to cannabis show an 8.6% reduction in cerebellar white matter compared to males, leading to deficits in attention and decision-making throughout addiction [34].

17.5% of women do not know that cannabis is addictive, compared to 11.3% of men, so addiction is more likely to develop unknowingly [35].

Animal studies in rats show that the Tetrahydrocannabinol dose needed to develop tolerance is 30-40% lower in females than males, leading to a faster development of addiction [36].

Female rats require 10x less cannabis to experience analgesic effects compared to males, resulting in faster dependency in females when the same dose of cannabis is used for pain relief [37].

Abbeycare Pricing Bot

About the author

Philippa Scammell

Philippa Scammell MSci holds an integrated Master's degree in Psychology
from the University of York and has completed undergraduate statistical studies at Harvard University. Philippa has substantial experience in inpatient psychiatric care (Foss Park Hospital York), Research in Psychology at University of York, and group therapy facilitation (Kyra Women's Project). Philippa writes on clinical psychology and addiction recovery. Content reviewed by Laura Morris (Clinical Lead).

Last Updated: October 27, 2025