Does Alcohol Withdrawal Cause Diarrhoea?

Call our local number 01603 513 091
Request Call Back

Call our local number 01603 513 091
Request Call Back
Call our local number 01603 513 091
Request Call Back
quotation_mark

KEY TAKEAWAYS

Alcohol withdrawal causes diarrhoea by: 

  • Increasing colorectal transit time by 33.73% and rectosigmoid transit time by 250% [1]
  • Causing a five-fold increase in translocation of gut microflora-derived lipopolysaccharide [2]
  • Causing adrenaline levels to rise by 98.9% and noradrenaline levels to rise by 82.4% [3]
doesalcoholwithdrawalcausediarrhoea abbeycare 1

Physiological Causes Of Alcohol Withdrawal Diarrhoea

Gastrointestinal Disruption

Colorectal transit time increased by 33.73%, and rectosigmoid transit time increased by 250% in withdrawing alcoholics suffering from diarrhoea [1].

Alcohol-withdrawing rats experiencing diarrhoea had a five-fold increase in translocation of gut microflora-derived lipopolysaccharide in the first 30- 90 minutes of diarrhoea [2].

doesalcoholwithdrawalcausediarrhoea abbeycare 1

Hormonal Imbalance

Adrenaline levels rise by 98.9%, and noradrenaline levels rise by 82.4% during withdrawal, triggering the body's fight or flight response and causing diarrhoea [3].

Electrolyte Imbalance

Hyponatremia occurs in 72.8% of alcoholics during withdrawal, causing a 16% increase in stool water content, resulting in diarrhoea [4] [5].

An 8% fall in calcium and a 5% rise in magnesium during alcohol withdrawal disrupt the absorption of fluids to the intestines, resulting in diarrhoea [6].

ImmediateHelp_CallImg

Withdrawal Management Medication Side Effects Causing Alcohol Withdrawal Diarrhoea

7.6% of patients using disulfiram during withdrawal experienced diarrhoea [7].

2% of patients using naltrexone during withdrawal experience diarrhoea [8].

20% of patients using acamprosate during withdrawal experience diarrhoea [9].

18% of patients using SSRI's during withdrawal experience diarrhoea [10].

What Factors Change Alcohol Withdrawal Diarrhoea?

Age

Renal function is lowered by 50% in the elderly, reducing hepatic clearance by 30% and resulting in diarrhoea [11].

Polypharmacy, specifically when combining alcohol with drugs proven to cause diarrhoea (e.g. Neomycin, Colchicine, Lactulose, Sorbitol) result in diarrhoea in elderly patients [12].

Gender

Oestrogen in women decreases by 11% during alcohol withdrawal, decreasing oestrogen's ability to regulate gut motility, resulting in diarrhoea [13].

Women metabolise alcohol 43% slower than men, increasing cortisol concentrations by 50%, resulting in diarrhoea [14] [15].

Genetics

Genetics that change alcohol withdrawal diarrhoea are:

  • ADH1B carriers have 79% higher acetaldehyde levels, resulting in diarrhoea symptoms during withdrawal [16]
  • ADH1B*2 alleles have 102% higher alcohol elimination rate, reducing alcohol withdrawal symptoms such as diarrhoea [16]
GetConfidentialHelp

History Of Alcohol Abuse

6% of binge drinkers consuming 4 or more drinks per day experience diarrhoea in alcohol withdrawal [17].

In a case study of a 54-year-old man withdrawing after drinking every day for 34 years, acute diarrhoea-induced shock occurred during withdrawal despite the patient being treated with 0.5g of potassium chloride twice per day [18].

Conditions Typically Confused For Alcohol Withdrawal Diarrhoea

  • 75% of inflammatory bowel disease sufferers and 43% of irritable bowel syndrome sufferers experienced gastrointestinal symptoms, including diarrhoea when consuming alcohol [19]
  • 75% of alcoholics with lactose intolerance reported diarrhoea during alcohol withdrawal, with symptoms disappearing after 8-10 days cessation of alcohol and lactose [20]
  • Clostridium difficile infection is an infection that causes diarrhoea, but is caused by the presence of Clostridioides difficile bacteria in the gut, rather than alcohol withdrawal [21]
Abbeycare Pricing Bot

About the author

Harriet Garfoot

Harriet Garfoot BA, MA has an Undergraduate degree in Education Studies and English, and a Master's degree in English Literature, from Bishop Grosseteste University. Harriet writes on stress & mental health, and is a member of the Burney Society. Content reviewed by Laura Morris (Clinical Lead).

Last Updated: January 31, 2025