Codeine Detox

Call our local number 01603 513 091
Request Call Back

Call our local number 01603 513 091
Request Call Back
Call our local number 01603 513 091
Request Call Back
quotation_mark

KEY TAKEAWAYS

Codeine detox is: 

  • A 7-day process that uses 2/0.5 - 32/8mg Suboxone to mitigate abdominal pain, hand tremors, and diarrhoea high-level use (≥30 tablets daily) of codeine [1] 
  • Symptomatically treated with 50 -150 µg clonidine to manage restlessness, lacrimation, and irritability by minimising sympathetic outflow within 48 hours of detoxing [1] 
codeinedetoxv2 abbeycare 1

How Is Detox For Codeine Done In A Controlled Setting?  

A detox for codeine is done in a controlled setting by:  

  • Administering standardised assessment tools (e.g. SDS, ASI) to predict the severity of withdrawal based on the amount of codeine taken daily (e.g. high-level use > 16 tablets daily = severe withdrawal expected) [1]
  • Conducting 6-hourly evaluations using The Clinical Opiate Withdrawal Scale, to develop an appropriate medication regimen after establishing the level (e.g. COWS: 13 – 24 = moderate) of joint pain, abdominal cramps/spasms, and restlessness [2]
  • Providing up to 8/2mg of Suboxone with 2-hourly monitoring 12 – 24 hours after the last dose of codeine and stabilising patients on a maximum daily dose of 32/8mg for around 1 week to mitigate severe withdrawal (e.g. COWS > 36) [3]
  • Symptomatically treating agitation, muscle/joint, and abdominal pain developing within 6 - 24 hours of cessation using 50 - 150 µg clonidine, 400mg ibuprofen, or 20mg Hyoscine butylbromide as needed for 5 - 10 days [1][2]
Codeine Detox Abbeycare

Physical Symptoms Of Codeine Detox

Muscle Aches And Joint Pain

Body aches are a physical symptom of codeine detoxification experienced by 98% of patients who withdraw after prolonged use (e.g. 14 years) as the body struggles to naturally produce endorphins due to the loss of mu (μ) receptor stimulation after abstaining [4]:

  • Diffuse body pain typically develops within 4 – 48 hours of codeine cessation and lasts for an average of 4 – 5 days in patients who previously abused 60 – 500ml of codeine-containing cough syrup daily for 4 years [4]
  • Aches and pains usually peak during days 2 - 4 and are exacerbated by disruptions in pain signalling and perception caused by imbalances in excitatory (+22% glutamate) and inhibitory (-24% GABA) neurotransmission after 5 years of codeine abuse [2][5]
  • Joint pain is less severe (e.g. 1 = mild diffuse pain vs 4 = unable to sit still due to discomfort) during a detox from codeine compared to other opiates, i.e. morphine, due to a weaker analgesic effect and Ki nM (734.2 vs 1.168) at the μ-receptor [6]

Nilsen et al. (2010) found that a 39-year-old female's musculoskeletal pain was 40% less intense within 8 weeks of receiving a codeine taper during detox after previously abusing 210mg daily for 3 years [7].

Restlessness And Hand Tremors

Psychomotor agitation is a physical symptom of codeine detoxification because autonomic and motor signalling is no longer suppressed by taking 100mg of codeine daily, resulting in fidgeting, an inability to sit still, or finger tapping due to CNS excitation [8].

Restlessness may present as anxiousness in up to 83% of patients who previously abused up to 500 mL of codeine-based cough syrup (e.g. Phensedyl) daily for a minimum of 5+ months, developing within 12 hours of discontinuation and lasting for around 5 days [4].

Tremors during withdrawal from codeine are typically localised (e.g. hands) rather than systemic (e.g. full body) as codeine is 10 times less potent than morphine compared to other opioids (e.g. fentanyl), which is 100 times more potent than morphine [9].

Clinicians administer COWS to evaluate the intensity of restlessness (e.g. 3 = frequent shifting or extraneous movements of the legs/ arms) and tremors (e.g. 4 = gross tremor or muscular twitching during observations of outstretched hands) during a detox from codeine. 

50 - 150 µg of clonidine is administered every 6 hours as needed for up to 5 days during detox to manage restlessness and hand tremors developing within 4 - 48 hours of codeine cessation [1][4].

Abdominal Cramps

Abdominal cramps/spasms are a physical symptom of codeine detoxification because the enteric nervous system (ENS) becomes overactive and gut motility accelerates after being suppressed during active use, leading to vomiting and diarrhoea in up to 85% [10].

78% of daily codeine users have loose bowel movements within 2 days of detoxing due to the loss of μ receptor stimulation in the gastrointestinal tract, typically easing within 5 days as phasic contractions are stabilised by the recovery of the ENS after abstaining [4].

Clinicians use the Clinical Opiate Withdrawal Scale to gauge the intensity of gastrointestinal upset experienced within the past 30 minutes (2 = nausea or loose stool vs 5 = multiple episodes of vomiting or diarrhoea) in patients detoxing from codeine.

20mg Hyoscine butylbromide is provided every 6 hours to manage abdominal cramps/spasms as needed, alongside 2mg loperamide and 10mg metoclopramide to control diarrhoea, vomiting, and nausea developing within 48 hours of abstaining from codeine [2][4].

Lacrimation

Lacrimation is a physical symptom of codeine detoxification that occurs in 98% of patients, as the lacrimal glands become overstimulated within 2 days of cessation due to the rebound of parasympathetic activity after being inhibited during active use [4]. 

Lacrimation typically peaks during days 2 – 4 of codeine cessation and lasts an average of 5 – 10 days, and assessment tools (e.g. SOWS, COWS) are used to distinguish between “normal” and “abnormal” tearing during detox by [2]:

  • Asking patients to rate the statement “My eyes are tearing” using a 0 – 4 rating scale where 0 = not at all, 1 = a little, 2 = moderately, 3 = quite a bit, and 4 = extremely
  • Conducting physical observations to evaluate the production of tears not accounted for by a cold/flu or allergies, and establishing whether patients have unusually moist eyes or tears streaming down the cheeks using a 4-point scoring system [2]
GetConfidentialHelp

Psychological Symptoms Of Codeine Detox 

Depression

Depression is a psychological withdrawal symptom of codeine detoxification due to the rebound of low mood, energy, and motivation;  and a 35% reduction in the availability of dopamine transporters in the striatum after 12+ months of codeine misuse because [11][12]:

  • 45% of users take around 240mg of codeine daily to “feel better when down or depressed” due to the drug’s ability to enhance mood for around 4 hours at a time, and some patients claim, “It gave me direct depression ... from coming off.” [13][14]
  • Abusing prescription analgesics for ≥ 6 months increases the risk of depression by 50% due to disruptions in dopaminergic signalling, and codeine patients have abused the drug for an average of 4 years before entering treatment [4][15]

Nilsen et al. (2010) found that 18% of patients experienced depression during detox after abusing codeine for 1 – 3 years, although the intensity decreased from 2 (moderate) to 0 (none) within 3 months of treatment after previously taking 210 - 240mg daily [7].

Irritability

Irritability is a psychological withdrawal symptom of codeine detoxification caused by μ-receptor deactivation and neurochemical imbalances (e.g. a 35% decrease in dopamine) in brain regions responsible for mood regulation (e.g. striatum) after 1 year of use [11]. 

Irritability typically develops within 24 hours of codeine cessation and peaks during days 2 – 3, as some users claim “I’d get very, very agitated” for around 5 - 10 days after abstaining because misusing codeine for ≥ 3 months increases mood swings by 2-fold [2][14][16].

Irritability is typically assessed on a 6-hourly basis using the Clinical Opiate Withdrawal Scale, where a score of 4 is assigned to patients who appear so irritable that participation in the assessment is difficult, compared to a score of 0 if no irritability is present [2]. 

Emotional Restlessness

Emotional restlessness occurs during codeine detoxification due to excitatory-inhibitory imbalances (e.g. a 24% reduction in GABA + a 22% increase in glutamate) in brain regions involved in emotional processing (e.g. medial prefrontal cortex) after 5 years of use [5].

Emotional restlessness typically develops within 2 days of withdrawing from codeine and is exacerbated by insomnia and anxiety in 83 – 100% of patients who abstain after heavy use (e.g. 60 - 500ml of codeine-containing cough syrup daily) [4]. 

Slight (1935) studied a 44-year-old man who became nervous within 7 hours of last taking codeine that was initially prescribed for “foot pain”, although emotional symptoms (e.g. irritability) resolved within 1 week after previously injecting 80mg of codeine per day [17].

SOWS is used to assess signs of emotional restlessness by asking patients to rate statements such as “I feel anxious” and “I feel restless” from 0 – 4 to describe the current intensity (e.g. 0 = not at all vs 4 = extremely) during each day of codeine detoxification.

ImmediateHelp

Positive Benchmarks Of Codeine Detox 

Return Of Normal Bowel Function 

Complete resolution of diarrhoea within 5 days is a positive benchmark of codeine detoxification as intestinal contractions are inhibited by taking 2-16mg/d of loperamide to manage loose bowel movements experienced by 78% of patients within 2 days of cessation [2][4]. 

Stiles et al. (2010) found that the intensity of diarrhoea decreased by 3-fold at the 12-week follow-up in 5 patients who received an 8-week codeine taper after abusing high doses (e.g. 420mg/d) that were initially prescribed for neuropathic or musculoskeletal pain [7]. 

Patients typically have healthy bowel movements (1-2 daily) within 10 days of abstaining from codeine after having ≥ 3 loose stools daily during the first 5 days, and constipation (< 3 stools p/wk) with related symptoms (e.g. abdominal bloating) during active use [2][4].

Reduced Cravings

Cravings/urges to use codeine mid-detox are rated 2 (moderate) on a 0 - 3 intensity scale, compared to a 1 (small) post-detox and a 0 (none) at the 3-month follow-up in patients who previously abused 180mg of codeine daily for 1 year [7]. 

Mattoo et al. (1997) found that the urge to use codeine subsided within 4 - 5 days of detoxing after 100% of patients with a long-term codeine addiction (e.g. 14 years of daily use) felt the desire to take the drug within 4 - 48 hours of abstaining [4].

Fors et al. (2010) found that cravings/urges to take codeine completely subsided by the end of treatment in 70% of patients who previously abused up to 420mg of prescribed codeine daily before receiving an 8-week taper during detox [7]. 

Fors et al. (2010) found that cravings/urges to take codeine completely subsided by the end of treatment in 70% of patients who previously abused up to 420mg of prescribed codeine daily before receiving an 8-week taper during detox [7]. 

Improved Mood Stability

A 50% decrease in anxiousness is a positive benchmark of codeine detoxification because patients no longer feel “very agitated and in complete shutdown” within 12 weeks of abstaining after previously abusing 240mg of codeine daily for 10 years [7][14]. 

Nilsen et al. (2010) found that a 29-year-old female's scores on the mental health subscale of the SF-36 HRQL increased by 67% within 3 months of detoxing after previously taking 240mg of codeine daily for 1 year and experiencing moderate depression mid-detox [7].  

Slight (1935) studied a 44-year-old man whose nervousness, sweating, and irritability subsided within 1 week of receiving a medically supervised detox after previously abusing 80mg of codeine daily, alongside heroin and morphine for around 9 years [17]. 

How Does Dehydration Alter Codeine Detox Protocols?

Being dehydrated alters codeine detoxification protocols because 78% have loose bowel movements during the first 5 days, and patients who pass  8 loose or watery stools within 24 hours are 9 times more likely to become severely dehydrated, requiring [4][18]:

  • Regular encouragement to consume “light” balanced meals with protein (e.g. meat), complex carbohydrates (e.g. wholegrain bread), and dietary fibre (e.g. berries) alongside 2 – 3L of liquid (e.g. water) daily throughout the withdrawal period [2] 
  • Nutritional/fluid intake and output, urea electrolytes, creatinine, liver function, and acid-base balance evaluations and monitoring with 2 – 5L of intravenous rehydration with potassium or magnesium salts if needed when COWS > 36 [2] 
  • Higher doses of loperamide (e.g. 16mg vs 2mg) to inhibit peristalsis and electrolyte loss with ongoing monitoring to assess the number of loose stools after each dose and general gastrointestinal functioning [2] 

Codeine Detox At Abbeycare 

Codeine detox at Abbeycare is typically a 7-day process that takes place as part of the 28-day full rehabilitation programme to mitigate codeine withdrawal symptoms (e.g. emotional restlessness, hand tremors) by: 

  • Providing suboxone around 12 – 24 hours after the last use of codeine and symptomatically treating joint pain or abdominal/bowel spasms with ibuprofen or hyoscine butylbromide as needed after being examined by the medical team 
  • Assigning each patient with a key worker during the first 7 days to ease nervousness and apprehension by providing 1-1 support and developing a personalised care plan in a calm and relaxed environment
  • Using assessment tools (e.g. COWS) and regular supervision to evaluate changes in gastrointestinal functioning (e.g. number of vomiting/diarrhoea episodes), mood, and perspiration (e.g. sweat streaming off face) during the first week of treatment  
Abbeycare Pricing Bot

About the author

Mischa Ezekpo

Mischa Ezekpo has a Bachelors degree in Psychology from Northumbria
University, and a Masters degree in Childhood Development and
Wellbeing, from Manchester Metropolitan University. Since 2018, Mischa
has written and published work on Addiction, Mental Health, Depression, and Eating Disorders. Content reviewed by Laura Morris (Clinical Lead).

Last Updated: November 4, 2025